How about Wafrn?

They have ISOs with Nvidia stuff pre-installed. I haven’t used it, though.

I found a guide on setting up Bazzite for modded Skyrim. I don’t know how accurate or up to date it is because I don’t have Skyrim, but it’s probably a good place to start.

Another option is Nobara. It’s Fedora-based and gaming focused, while not being immutable. Additionally it’s developed by Glorious Eggroll himself.